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PharmFast
Validated NONMEM Acceleration Engine

Reproduces NONMEM 7.6 estimates inside a scoped qualification envelope. Known unsupported constructs are refused precisely; the live validator is authoritative for each exact deck, dataset, and estimator combination.

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64/64

Validation Pack

PASS vs real NONMEM 7.6

≤ 3

Validated Accuracy

|ΔOFV|; most exact

16.4×

Scoped FOCE Speed

up to, K=4; both converged

Key Features

Validated NONMEM 7.6 Estimates

64/64 validation-pack scenarios PASS vs real NONMEM 7.6, with |ΔOFV| ≤ 3 and most exact.

Fail-Closed Model Gate

Known unsupported constructs are refused with a precise reason, and every marketed deck must pass its exact live validation gate.

Scoped FOCE Acceleration

Up to 16.4× faster on a high-random-effect-dimension FOCE fit (K=4), with both engines converged.

Explicit Performance Boundaries

On the retained single-fit comparison, NONMEM was faster.

See it in action

Load a control stream and dataset, validate the exact deck, run the fit, and inspect the engine-reported route and results. When a bundled example includes a frozen NONMEM reference, the workbench shows the comparison explicitly.

Bundled examples for selected validated model families.
Bundled examples for selected validated model families.
Fit results report the route and convergence state the engine actually returned.
Fit results report the route and convergence state the engine actually returned.
Frozen NONMEM comparisons appear only where a reference is attached.
Frozen NONMEM comparisons appear only where a reference is attached.

A Validated Acceleration Layer

PharmFast is a fail-closed whitelist, not a general NONMEM interpreter. Supported workflows run inside the published envelope; unsupported constructs stop with a precise reason instead of returning a plausible result.

Evaluate your exact workflow

Open the workbench to validate a deck, or contact us about a scoped qualification and acceleration pilot.

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